The principal cytochrome P450 isoenzyme included appears to become CYP2E1, with CYP1A2 and CYP3A4 as more pathways. About eighty five% of the oral dose appears during the urine in 24 several hours of administration, most as the glucuronide conjugate, with smaller amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity data.Reco